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Concerning the other major criterion of cEDS, gJHM remains undeniably characteristic of the disorder, even if in our sample a BS 5 was identified in less than 60% of patients and it is common to all EDS subtypes and other HCTDs [1, 9, 28, 30, 36,37,38,39, 47, 50, 69, 70]

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The degree to which the harm is reduced is still debated (5), despite tobacco companies' own studies and marketing latching on to the established "95% less harmful than cigarettes" claim associated with e-cigarettes