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The specific parameters for analysis of each of these four subsets that differ from those above are as follows: (1) KRT8 high /secretory cells: Dataset integration was carried out with the top 3000 genes, UMAP was created with n.neighbors = 50, min.dist = 0.3, and SNN clustering was done using the Louvain algorithm, k.param = 50, and resolution = 0.54

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Minor contributions to drug metabolism have been observed in vitro from CYP1A1, CYP2C8, and CYP2C18, though these enzymes are less relevant in vivo due to their lower hepatic expression compared to CYP3A4 (Shimada et al., 1994)

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Once prepared, you can begin cleaning