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The US Food and Drug Administration (FDA) stated in 2013 that there are no significant safety concerns associated with the use of more than one form of over-the-counter (OTC) nicotine replacement therapy at the same time, or using OTC NRT at the same time as another nicotine-containing product, like cigarettes

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Wicked problems can productively be viewed within the environment of the larger complex adaptive system, which describes the wider landscape that surrounds and influences the problem