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Environments acting during early embryogenesis (e.g., when global erasure and re-establishment of DNA methylation occur) may induce extensive, soma-wide modifications of DNA methylation, whereas environments acting later during life are more likely to induce less extensive, tissue-specific modifications of DNA methylation ( Figure 1 )

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doi: 10.1093/ntr/ntac205 18

Analysis performed by the American Lung Association Epidemiology and Statistics Unit using SPSS software