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Furthermore, some of these drugsparticularly insulin and sulfonylurealead to undesired risks including hypoglycemia and weight gain [5]

Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells

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Seek out another type of therapy While anti-obesity medications can offer significant benefits, patients have other therapies available

This approach maintains clinical efficacy while reducing nausea and gastrointestinal side effects that some experience at standard doses

Thus, the different volume regulation by SGLT2-I may limit the aberrant neurohumoral and RAAS stimulation that occurs in the setting of volume depletion (54, 55)