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4-week minimum interval between dose increases aligns with the 4-5 week time needed to reach steady-state plasma concentration at each dose level

For some people, this is the maximum dose of 2.4 mg or 2 mg

Standard evaluation typically involves thyroid ultrasound with standardized risk stratification (ACR TI-RADS or similar system), fine needle aspiration biopsy for nodules meeting size and suspicion criteria, serum calcitonin measurement if medullary thyroid carcinoma is a concern, and review of family history for MTC and MEN 2

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