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The tobacco "powder" or snuff became known as "Santacroce powder" or "santa polvere," that is, "holy powder." Pope Pius IV tasked Cistercian monks with growing tobacco in the Lazio region in the 16th century, and other monastic communities started growing the crop in other regions in Italy

and is the leading cause of cancer worldwide, causing almost six million deaths each year

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Over time, a small proportion of lesions will undergo malignant transformation, which is generally amenable to surgical excision