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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Henningfield JE, Stapleton JM, Benowitz NL, Grayson RF, London ED

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Acetylcholine from brainstem nuclei might exert a profound modulatory effect on both populations of VTA neurons through the activation of nAChRs

Therefore, using tabacco instead of tobacco can create ambiguity and make it difficult for readers or listeners to understand your intended meaning