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Methamphetamine triggers a massive dopamine release -- far exceeding natural rewards -- and simultaneously damages the dopamine-producing neurons responsible for baseline pleasure

American Journal of Health Promotion, 26(6), 331-332

They repeated this for the same participants at ages 19 and 23
THC affects everyone differently, based on: size, weight and health whether the person is used to taking it whether other drugs are taken around the same time the amount taken the strength of the drug (varies from batch to batch) the environment (where the drug is taken) whether the person has pre-existing mental health conditions (see cannabis (THC) and mental health section below for more information)

All of them had been smokers

A handful of other smoke detectors also have integrated carbon monoxide sensors, even though they only have a single type of smoke-sensing sensor
