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Impact of canagliflozin on kidney and cardiovascular outcomes by type 2 diabetes duration: a pooled analysis of the CANVAS program and CREDENCE trials

In murine models of obesity and diabetes, administration of the chemical chaperones phenyl butyric acid (PBA) and tauro-ursodeoxycholic acid (TUDCA), increased systemic insulin sensitivity, established normoglycemia, reduced fatty liver disease, and suppressed inflammatory signaling (137)

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Unexpected safety-issues and important side-effects ( This review summarizes the most recent studies that reframe our understanding of the physiology of GLP-1 in health and disease

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