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One of the most robust findings in genome-wide association studies is that variants in the CHRNA5 / A3 / B4 cluster on chromosome 15q24-25.1 show a significant association with both nicotine dependence and lung cancer 10

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34 Recent studies of nicotine salt-based electronic nicotine delivery systems (ENDS) have shown that EC aerosols can contain acetaldehyde, acrolein, and formaldehyde, while 9799% of emitted particles fall within ultrafine or fine size ranges

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