cigarette smoke induces cytoplasmic p53 accumulation Mitochondrial DNA is a key driver in extract-induced IL-6 expression Tobacco smoke condensate-induced senescence in

HBE cells from both groups were exposed to the smoke of eight cigarettes and evaluated for AIF and EndoG translocation by western blotting

This was made apparent by changes in the inflammatory mediators PGE2 and IL-6 secreted by smoke exposed cells, through experiments showing conditioned media from smoke exposed tumor cells can rewire PBMC programing and differentiation, and by changes in the tumor immune microenvironment we found in vivo with smoke exposure

doi: 10.1016/j.heliyon.2023.e15155 90 RahbarSNovinMGAlizadehEShahnaziVPashaei-AslFAsrBadrYAet al

P., Saville, M

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Can mutp53 be used as prognostic marker for tumors to make more accurate diagnosis, and monitor the response to treatment in cancer patients