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Description
E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis

But, of course, filtered cigarettes had an image problem: no man wanted to smoke them
This is supported by research conducted with mecamylamine, which readily crosses the blood brain barrier, and hexamethonium, which does not cross the blood brain barrier

PMID 17600271

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License: CC BY 2.0 People have been smoking tobacco recreationally for thousands of years