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Those are indicators that there should be a significant health benefit

Sixth, as our study used a cross-sectional design, we cannot determine causality in the association between initiation age of cigarette smoking and related factors
Increased abundance of Actinobacteria[p] (Beta SE: 0.051 0.019, P = 7.74e 03), Bifidobacteriales[o] (Beta SE: 0.050 0.016, P = 1.73e 03), Bifidobacteriaceae[f] (Beta SE: 0.050 0.016, P = 1.73e 03), and Bifidobacterium[g] (Beta SE: 0.049 0.016, P = 1.79e 03) lead to later smoking initiation

CBD cigarettes and pre-rolls may help some smokers reduce their tobacco use

PloS One 8, e63514