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In brief, the major mechanisms of smoking-induced CV disease (many of which are overlapping) are 1) oxidative injury, 2) endothelial damage and dysfunction, 3) enhanced thrombosis, 4) chronic inflammation, 5) hemodynamic stress, 6) adverse effects on blood lipids, 7) insulin resistance and diabetes, 8) reduced oxygen delivery by red blood cells, and 9) arrhythmogenesis

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Pharmacologic Management When behavioural counselling alone does not result in cessation, pharmacologic therapy may be considered as an adjunct to support quitting during pregnancy

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