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These GLP1 RA initiators were not included, resulting in a final study population of 1778 GLP1 RA and metformin initiators, respectively (Figure 1)

Compared with DPP-4 inhibitor users, those taking GLP-1RAs had a 13% lower risk of rheumatoid arthritis, 18% lower risk of gout and a modest reduction in osteoarthritis incidence over one year

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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose

doi: 10.1016/j.clnesp.2024.08.005 529 FahmyAM
