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The evidence showed that among adult men in northern Sweden the dominant transition is from smoking to snus, not vice versa

(63), may reflect differences in study design, sample size, or measurement techniques

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(4) Warnings and Precautions Neuropsychiatric Adverse Events: Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide

Industry representatives say the FDAs refusal to approve more options has forced it into an untenable position