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These peptides have been extensively studied because of their structural diversity, their wide-range of pharmacological effects, and their potential to serve as pharmacological tools, such as ion channel [21,22,23,24] and G-protein-coupled receptor [25,26] modulators, as well as inhibitors of enzymatic activity, including angiotensin-converting enzyme (ACE) [27,28,29,30,31,32,33,34] and matrix metalloproteinases [35]