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Belladonna, stramonium, lobelia, henbane, atropine, and even cannabis were packaged in cans and placed on shelves in pharmacies

IARC, Lyon, FR, pp 3391 Dipple A, Moschel RC, Bigger CAH (1984) Polynuclear aromatic hydrocarbons

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This entrenched use of reduced-risk products shifts the competitive landscape, requiring traditional NRT players to focus on differentiation through clinical efficacy, combination therapy bundles, and targeted medical channels

However, the comprehensive review recently published in the journal Carcinogenesis provides data from numerous studies indicating that exposure to aerosols from nicotine-containing e-cigarettes is associated with some of the key features of carcinogenesis, such as DNA damage, oxidative stress, and epigenetic changes, which contribute to an increased risk of oral cavity cancer, lung cancer, and other forms of cancer among people who use these devices, even if they have not been users of conventional tobacco products