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3.10 Animal studies of the interactions between cigarette smoke exposure and other agents Fourteen chronic inhalation studies (whole-body or nose-only exposure) with mainstream cigarette smoke in rats and mice were reviewed by Coggins (1998) and the results and histopathological changes contrasted with epidemiological studies in humans

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In an important study by Khokhar and Tyndale, the authors found that 7 days of nicotine treatment increased CYP2B expression in the brain, but not liver, and surprisingly, this change in metabolism was sufficient to potentiate the sleep-inducing effects of the general anesthetic propofol in male rats (167)