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Emerging evidence suggests that tobacco use may accelerate this progression through multiple pathways, though most data relate to smoked tobacco

Findings In this randomized clinical trial that included 2149 adult smokers, 40% of smokers in the pictorial arm made a quit attempt compared with 34% in the text-only arm, a significant difference

Most e-cigarette users continue smoking traditional cigarettes

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Although the effects of smoking are not the same as those of nicotine, there is clinical evidence that suggests that nicotine and/or its metabolites, such as cotinine, are responsible for the beneficial effect of smoking in patients with active UC