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In further sub-group analyses, the association was significant in the studies that used the standardized ISAAC protocol (RR = 1.50, 95% CI 1.351.66), but not those that used their own protocol (RR = 0.96, 95% CI 0.881.08)

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A recent study showed that current nicotine e-cigarette users who were ex-smokers remained nicotine dependent and had higher nicotine dependence scores if they used e-cigarettes for a longer period of time or if they used more advanced nicotine e-cigarettes (related to size, battery powered, controls, etc.)