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Studies concluded that individuals with prior or consistent tobacco use were less likely to experience major symptoms related to GTS

Since residue 155 is located on the outer surface of the TMV rod, it is feasible that the mutation alters TMV surface chemistry

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Moreover, the median myosmine-nicotine ratio was 1.8% in smokeless-tobacco households versus 7.7% in cigarette-user households, confirming that contamination in the smokeless-tobacco homes came primarily from smokeless tobacco