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Nicotine stimulates nicotinic cholinergic receptors and indirectly causes the release of neurotransmitters such as noradrenaline, adrenaline, vasopressin, serotonin, -endorphin, and dopamine

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The affected group not only exhibited a higher prevalence of residing in smoking households, but urothelial carcinoma was diagnosed in 35.5% of dogs with measurable urinary cotinine levels, compared to only 15.5% in those with undetectable cotinine concentrations (p=0.016) 3

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