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Furthermore, it has been reported that whole particulate phase from traditional tobacco causes an increase in cytosolic Ca 2+ concentration, and components of tobacco such as 1-NH2-naphthalene, formaldehyde, nicotine, and nicotine-derived nitrosamine ketone may be involved [10]

Although multi-omics technologies have delineated characteristic microbial signatures associated with tobacco exposure, key questions regarding causality, reversibility, and therapeutic applicability remain unresolved

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It can also cause problems ranging from minor respiratory infections to stomach ulcers