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This can reduce anxiety associated with cravings and improve mood

[85] Nicotine also stimulates nicotinic acetylcholine receptors in the adrenal medulla, resulting in increased levels of epinephrine and beta-endorphin

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Like other addicting drugs, nicotine floods the brains reward circuits with a chemical called dopamine

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The authors summarized their findings with the explanation that: Our study had insufficient power to detect a modest association between smoking only marijuana and increased risk of COPD