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Last, edits to clarify language, as well as additional information from the recent 2020 Surgeon Generals Report on Smoking Cessation, have been provided in response to comments

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Epidemiological investigations and extensive genetic studies have begun to elucidate the environmental factors that might contribute towards ones risk and have revealed hundreds of genes linked to autism [ In utero exposure to nicotine has deleterious effects on prenatal neurodevelopment [114, 115]
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