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The initial symptoms are mainly due to stimulatory effects and include nausea and vomiting, excessive salivation, abdominal pain, pallor, sweating, hypertension, tachycardia, ataxia, tremor, headache, dizziness, muscle fasciculations, and seizures

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Higher doses like 15mg-30mg are for those who use edibles often and doses greater than 50mg are for medical marijuana patients or people experienced with THC

Clowes Memorial Award Lecture"
Despite significant inhibition of MAOA activity (Figures 5C,D), individual non-nicotine constituents caused no DA increase (Figures 3DF)

Similar to caffeine, nicotine is a stimulant and promotes alertness, cardiac activity, and concentration