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Phytopathology 77:1090-1093

As they were not edible and had a distinct smell to them, those leaves, which the Native Americans have been smoking for over 2 millennia for medicinal and religious purposes, were thrown overboard
Formaldehyde is predominately formed by the hydroxymethyl group of sugars [6,35]
It is widely accepted that smoke from different pyrolysed tobacco delivery devices (e.g

"Heat-not-Burn Tobacco Products: Tobacco Industry Claims No Substitute for Science"
