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Many times, the clot itself may cause no symptoms until it embolizes and becomes lodged in small blood vessels at distant sites in the body

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The associations between bone mineral density and long-term risks of cardiovascular disease, cancer, and all-cause mortality Lin Shi, Xiao Yu, Qingjiang Pang, Xianjun Chen, Chenghao Wang Frontiers in Endocrinology 4

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This would mean that Sanji is in a constant state of stress, which makes sense, seeing how he was first exiled from his family and then almost died from starvation after being attacked by pirates