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We also dont yet have decades-long data on the long-term health effects of chronic vaping, which is reason enough to be cautious, especially for young people and non-smokers

In July 2020, however, the FDA authorized PMI to market IQOS with the claim that switching completely from conventional cigarettes to IQOS reduces consumer exposure to harmful chemicals, even though most members of an official FDA advisory panel of external experts were skeptical of the claim

Cigarette consumption estimates for 71 countries from 1970 to 2015: systematic collection of comparable data to facilitate quasi-experimental evaluations of national and global tobacco control interventions

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Additional covariates for exacerbations included FEV 1 % predicted, SGRQ, and gastroesophageal reflux disease (GERD).18 , 19 Exacerbations in the year prior to enrollment (retrospective) and during longitudinal follow-up (prospective) were modeled using negative binomial regression with an offset for exposure time and zero-inflated negative binomial (ZINB) regression to account for the excess number of subjects who reported no acute episodes of respiratory disease (see18 for a description of modeling exacerbations)