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From a total of 16,168 subjects, 4,744 participants (2,162 men and 2,582 women) were included in this study after excluding individuals younger than 20 years of age and those with missing values for cadmium and smoking on questionnaires

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Furthermore, multiple studies have provided evidence for dose-dependent exposure effects on gray matter integrity within the insula [18, 85] and vmPFC [19, 22, 86] as well as within the lateral PFC [14, 20] and cerebellum [23]

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