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J Neurosci Methods 53(1):5563 Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodriguez de Fonseca F, Piomelli D, Ciccocioppo R (2011) Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition

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however, loss of response to anticonvulsant effects may develop with prolonged use