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However, high endogenous levels of both of these hormones may reduce the cannabis high by blocking THCA's effect on CB1 receptors

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Additionally, it has been found that dopamine receptor antagonists attenuated self-administration of nicotine (0.03 mg/kg/infusion) in male LongEvans rats while increases in extracellular dopamine concentrations in the nucleus accumbens (NAc) shell have been observed in male SpragueDawley rats with a preference to nicotine (Corrigall and Coen, 1991