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[39] First-time nicotine users develop a dependence about 32% of the time

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[DOI] [PubMed] [Google Scholar] [34].Brody AL, Mandelkern MA, London ED, et al

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4 In 2021, smoking alone was responsible for 2.25 million CVD deaths globally, mainly from ischaemic heart disease and stroke, confirming CVD as one the leading pathway of tobacco-attributable mortality