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This is consistent with a 2003 study in the International Journal of Pharmaceutics showing buccal caffeine delivery reaches peak plasma levels 2-3x faster than oral ingestion (PMID: 12576291)

Understanding this is important because you could have two regular smokers who age entirely differently

[16] Francona is the only manager in Major League history to win his first eight consecutive World Series games and just the second manager to guide two Red Sox clubs to World Series titles, the other being Bill "Rough" Carrigan, who led Boston to back-to-back championships in 1915 and 1916

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The authors of the publication close with a statement urging women to quit smoking before or, at worst, during pregnancy