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Taken together, all of the data concerning waterpipe tobacco toxicant content raise important concerns, as decades of research on cigarette smokers demonstrate that prolonged exposure to these toxicants leads to significant adverse health effects

However, evidence that ADHD symptoms improve with nicotine administration among nonsmokers suggests that there may be theoretical potential for a combined therapeutic effect for nicotine dependence and ADHD.[21,22] Bupropion is another effective smoking cessation treatment.[45,46] It has additionally shown efficacy in treating ADHD,[47] but has only been specifically investigated for smoking cessation in individuals with ADHD in one pilot study.[48] Further research is needed to determine whether bupropion can effectively treat both conditions simultaneously

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doi: 10.1016/j.bcp.2016.05.001 93 ZupaniECuratoCPaisanaMRodriguesCPoratZVianaASet al

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