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Key points: Large study consolidates previous evidence of link between smoking and changes in DNA Mothers of 13 per cent of 6,000 babies in study smoked regularly These babies had changes in DNA in over 6,000 places, about half these locations involved a single gene Doctors have long warned women to avoid cigarettes while pregnant because smoking can lead to stillbirth or babies born with cleft palate, lung disease, or neurobehavioural problems