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These transcription factors are involved in the synthesis of several antioxidant enzymes (e.g., glutathione reductase, glutathione peroxidases, glutaredoxin, and glutathione- S -transferase), many of which are closely related to the cellular antioxidant, glutathione (Espinosa-Diez et al

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GHK-Cu, a copper peptide found abundantly in the human body, which re energizes skin cells and creates an optimal environment for skin-cell health span

A randomised clinical trial involving patients with type 2 diabetes aged 70 years revealed that multifactorial interventions, including diet, physical exercise and optimal control of glucose and blood pressure, significantly improved the SPPB score after 12 months [236]

To discard a putative strain dependence of this phenotype, we constructed the ahpD in a D39 genetic background, the ancestral strain for R6 and R801 strains, and we found the same H 2 O 2 susceptibility observed in the R801 strain (Fig S3), and this will be discussed later