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However, the relationship was not simple and may change at very high exposure levels

Given the importance of biofilm formation for adhesion in the oral cavity [70], and the fact that cigarette smoke increased biofilm formation by specific bacteria and promoted colonization [34], it would be reasonable to suspect that oral microbiome might be the missed connectivity between smoking and infective endocarditis

Figure 1.4 Path that nicotine travels from the mouth to the brain

Reported results are mean (standard deviation) [median] unless otherwise stated

10.1111/j.1365-2125.2007.02846.x Summary Keywords adverse drug reactions, cytochrome P450, diabetes mellitus, drug-drug interactions, drug metabolism, smoking cessation Citation Bellanca CM, Augello E, Di Benedetto G, Burgaletto C, Cantone AF, Cantarella G, Bernardini R, Polosa R and the DiaSmokeFree Working Group (2024) A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

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