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A typical "smoker's face" can be described as having prominent facial wrinkles, an underlying bony structure, atrophy of the skin, mild orangish-red, or gray face complexion

These trends go on to show that emerging markets in Asia and Africa are critical for the tobacco industry, while cigarette consumption is beginning to decline in the developed world due to stronger government regulation

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HIV diagnoses have been rising nationally for White adults, in the transmission category of injection drug use, from 2013 to 2021 [46] and several local HIV outbreaks have been documented in the eastern and mid-western US [47, 48]

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