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Moreover, DPP4 acts as a physiological substrate for glucosedependent insulinotropic polypeptide (GIP), which is another incretin hormone, and its levels rise in response to the inhibition of DPP4 activity [51, 110]

42 Research has shown that GLP-1RA can trigger the AMPK pathway, resulting in anti-inflammatory outcomes

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The FDA has issued boxed warnings regarding potential thyroid tumor risk, although human evidence remains inconclusive [4347]

Conformational complexity of G-protein-coupled receptors

Both medications represent excellent options for managing type 2 diabetes, and either can significantly improve blood sugar control when used consistently alongside lifestyle modifications