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The National Cancer Institute states that cigarette smoking is the leading preventable cause of disease and death in the United States, as smoking causes cancers of all the following: lung, esophagus, larynx (voice box), mouth, throat, kidney, bladder, liver, pancreas, stomach, cervix, colon and rectum, as well as acute myeloid leukemia

In silico models, therefore, must necessarily be of a very diverse nature in order to integrate and interpret these data

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It identified "a serious problem" in 14 states and "a moderate problem" in another eight states

Reynolds Tobacco Co., et al