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In all studies, the AX iAECs alone or in co-culture with the hLMVECs were maintained and differentiated on the AX12 for three weeks prior to cigarette smoke treatment or exposure conditions, where ALI and stretch was initiated in specified experiments around 10 days prior to smoke exposure

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The study also noted that each lit cigarette releases 7,000 chemicals, 69 of which are considered to be cancer-causing substances

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