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In addition to their glycemic effects, DPP-4 inhibitors have the potential to decrease bone resorption, increase bone formation, and reduce the incidence of osteoporosis and fractures

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doi: 10.1038/s41591-018-0051-5

For now, and in the context of GLP therapy, it will be important to first better understand the insulin release and response kinetics in normal weight, nondiabetic patients before recommending these meds for a broader population.

78% of healthcare providers surveyed report that Hollywood, celebrities, and influencers embrace of GLP-1s for weight loss has harmed patients realistic expectations of the medication