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Retrieved from Ng, M., Freeman, M.K., Fleming, T.D., Robinson, M., Dwyer-Lindgren, L., Thomson, B.,

[58] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain

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Data collected during method development indicates that a significant amount of ammonia is effectively trapped in the filter, which in part explains the apparent lower rate of transfer of ammonia from tobacco filler to smoke