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the pipe smoking "noble savage", solemn contemplation by Classical Roman ruins, scenes of an artist becoming one with nature while slowly toking a pipe

Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase

[33] Tobacco was introduced around 1600 by French merchants in what today is modern-day Gambia and Senegal

This iron [dysregulation] drives oxidative stress, mitochondrial dysfunction, and increased -synuclein [protein] expressionhallmarks of neurodegenerative disease, Chen said

doi: 10.1016/j.bbcan.2020.188438