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For instance, persistent heartburn and peptic ulcers among others while at risk for the development of GERD or IBS due to prolonged use

For example, Christensen et al

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92 However, in a double-blind, placebo-controlled study examining responses during an emotional face task in women who were randomized to either active OC or placebo, women taking OCs exhibited lower emotion-induced reactivity in the left insula, left middle frontal gyrus, and bilateral inferior frontal cortex compared to those randomized to placebo

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A French study from the same year found similar results, but it also discovered that e-cig use among smokers increased the risk of tobacco use relapse