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These data advance the concept that significant increase in the concentrations of nicotine and cotinine, significantly higher levels of triglycerides, VLDL-C, total cholesterol (No significant change in khaini users), greater levels of protein carbonyls, peroxynitrites, malondialdehyde, and nitric oxide (No significant change in experimental groups), diminished levels of hemoglobin, HDL-C (No significant change in gutkha group), observed in the plasma of gutkha and khaini users compared to normal healthy controls

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