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Interestingly, preliminary evidence has also inferred that cardiac damage may be impacting males faster than females [97], primarily due to sex-dependent differences in nicotine metabolism [97]

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Most study subjects decreased the number of combusted cigarettes they smoked each day by greater than 80 percent, from an average of 13-16 cigarettes per day at screening to 1-2 by day 59

For most flavor chemicals, one LD 50 value was available, but if multiple were given, we chose the LD 50 value reported in the journal of Food and Cosmetics Toxicology

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